主 讲 人 ：Yoshihiro Sato教授（日本北海道大学）

报告题目： Utilization of CO₂ as a C1 Building Block in Organic Synthesis

报告时间： 2017年11月19日（周日）上午10：00

报告地点： 下沙校区D楼408室

Yoshihiro Sato教授

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Yoshihiro Sato，日本北海道大学教授，药学院院长。1984-1988年，北海道大学学士；1990年，获北海道大学硕士学位；1993年，获北海道大学博士学位。1990-1997年，任北海道大学助理研究员。1997-1998年，在美国斯坦福大学做博士后研究，师从于美国科学院院士Paul A. Wender教授。1999年任北海道大学讲师，2001年晋升为副教授，2004年晋升为教授，2017年任职药学院院长。Yoshihiro Sato 教授主要从事有机合成、有机金属催化等方向的研究。先后获得The Pharmaceutical Society of Japan Award for Young Scientists, Banyu Young Chemist Award, Thieme Journal Award, ACP Lectureship Awards等荣誉。

Abstract: Carbon dioxide (CO₂) is attractive to synthetic organic chemists as an abundant, cheap, and non-toxic carbon source, and the utilization of CO₂ as a C1 buliding blocks in synthetic organic chemistry should bring us a great advantage, especially for realizing the environmentally benign processes. However, CO₂ is very stable chemical substances, and how we can bring out the reactivity of CO₂ is important. CO₂ has mainly two reactivities; one is electrophilicity of the center carbon of CO₂, and the other is that C=O double bond can be activated by transition metal complexes. With respect to the former reactivity, we recently developed the synthesis of a-amino acids by the reaction of a-amino metal species, prepared from a-amino sulfone and bimetallic reagent such as TMS-SnBu₃¹ or pinB-SiMe₂Ph², with CO₂. More recently, we reported the transition metal-catalyzed carboxylation of nucleophilic p-ally metal species using CO₂.^3,4 With respect to the latter reactivity, we developed the synthesis of a chiral b-amino acids⁵ or b-aryloxy carboxylic acids⁶ through combination of nickel-catalyzed carboxylation of ynamides or aryl ynol ethers and rhodium-catalyzed asymmetric hydrogenation of the resultant carboxylated product. In this lecture, these reactions and the current results will be discussed.

References

1.     Mita, T.; Chen, J.; Sugawara, M.; Sato, Y. Angew. Chem. Int. Ed. 2011, 50, 1393.

2.     Mita, T.; Chen, J.; Sugawara, M.; Sato, Y. Org. Lett. 2012, 14, 6202.

3.     Mita, T.; Higuchi, Y.; Sato, Y. Chem. Eur. J. 2015, 21, 16391.

4.     Michigami, K.; Mita, T.; Sato, Y. J. Am. Chem. Soc. 2017, 139, 6094

5.     Saito, N.; Abdullah, I.; Hayashi, K.; Hamada, K.; Koyama, M.; Sato, Y. Org. Biomol. Chem. 2016, 14, 10080.

6.     Saito, N.; Sun, Z.; Sato, Y. Chem. Asian J. 2015, 10, 1170.